Since its introduction in 1998, Sildenafil citrate has proven to be a reliable therapy for Erectile Dysfunction – the male sexual disorder characterized by the inability to get full erections or maintain them for long. Brand Viagra uses this ingredient to hinder phosphodiesterase type-5-induced breakdown of cyclic guanosine monophosphate in the corpus cavernosum. More cGMP then relaxes the penile smooth muscle and widens blood vessels so that enough blood flows in to strengthen erections.
Regardless of whether you have decided on purchasing Brand Viagra or Generic Viagra, this mechanism is the same. Efficacy, however, varies from one formulation of the medication to another and from one dosage strength to another. Many Erectile Dysfunction patients have discovered that certain formulations of Sildenafil work better for them than others and that some dosage strengths are too harsh for them even if they don’t exceed the dosage limit.
The recommended dose of Sildenafil citrate for ED is one hundred milligrams and that is also the dosage limit. It is recommended that treatment is started with the one hundred milligrams dose. In general, one hundred milligrams Brand or Generic Viagra contains one hundred milligrams Sildenafil citrate and fifty milligrams of contains fifty milligrams Sildenafil citrate. Let us consider how to determine the right dosage for sildenafil use in ED therapy.
Sildenafil Citrate 50mg
Fifty milligrams Brand Viagra or Generic Viagra like Polypharma’s maxigra is comprised of hypromellose, titanium dioxide, triacetin, microcrystalline cellulose, lactose, anhydrous dibasic calcium phosphate, magnesium stearate, and a few other inactive ingredients in addition to fifty milligrams Sildenafil citrate as the active ingredient. This dose is typically formulated in film-coated tablets, soft gelatin tablets, and orally dispersing or sublingual tablets.
Doctors lower the dosage to fifty milligrams based on observed toleration and efficacy of the maximum dose. For example, if the one hundred milligrams dose produces strong and lasting erections but also causes shortness of breath as a side effect, the dose would have to be reduced to fifty milligrams. Note that this reduction is done irrespective of the particular tablet formulation in which this intermediate dose is administered.
Once it has been determined that a fifty milligrams tablet is sufficient for your erectile dysfunction treatment, you can get a prescription, which you can use to get Brand Viagra, or subsequently, any generic Viagra formulation you decide on purchasing after thorough research. Our TOP list of recommended online pharmacies will help you locate a trustworthy store where you can get effective 50 milligrams generic Viagra at low prices.
Sildenafil Citrate 100mg
Most Erectile Dysfunction patients will get a prescription for one hundred milligrams Sildenafil citrate. Careful research and clinical trials led to the formulation of this dosage strength as the maximum for ED therapy. Clinical trials have shown that a larger percentage of patients responded to this dose compared to the 50 milligrams dose and the 25 milligrams dose. At the same time, they revealed that 100mg is not for everyone.
Toleration is the main problem. Side effects like shortness of breath, insomnia, tachycardia, hypotension, sudden loss of hearing, reduced visual acuity, arthritis, asthenia, priapism, and paresthesia, to name a few, are more likely to occur in patients who use 100mg. These side effects are mostly related to preexisting conditions or contraindications and drug interactions.
For example, administration of Sildenafil citrate together with organic nitrites and nitrates like Nitroglycerin is contraindicated. Sildenafil citrate is also contraindicated for use with other PDE 5 inhibitors like those used in pulmonary arterial hypertension therapy. Sickle cell anemia, High Blood Pressure, Stroke, Chronic Heart Failure, Hypertrophic Cardiomyopathy, Pigmentary Retinopathy, and Multiple Myeloma are contraindicated with this medication.
Amlodipine, Alpha-blockers, Ritonavir and CYP3A4 inhibitors, and alcohol are drugs and substances that interact with Sildenafil citrate and are a valid basis for dosage adjustment from one hundred milligrams to lower doses. It is vital that you consult your doctor in order to get a comprehensive medical examination and report. That is the best way to determine the right dosage for you.
Those who favor over the counter generic sildenafil and eschew consultation with a qualified healthcare practitioner may find out about contraindications and drug interactions the hard way and may end up having to do visit a doctor to deal with the severe side effects. So while it’s nice to be able to obtain your prescription medications without a prescription, guard against trial and error.
All three original doses of Sildenafil citrate – one hundred milligrams, fifty milligrams, and twenty-five milligrams are useful for treating Erectile Dysfunction and impotence in men (particularly middle-aged men). The continued proliferation of generic Sildenafil citrate, however, has brought with it intermediate doses of the drug and as such it is imperative that patients and prospective buyers of the medication know the right dose for them.
Toleration and effectiveness after administration should help your doctor and you decide on the best dosage strength. Side effects like shortness of breath, insomnia, tachycardia, hypotension, sudden loss of hearing, reduced visual acuity, arthritis, asthenia, priapism, and paresthesia can be avoided by simply lowering the dose from the maximum 100 milligrams tablet to 25 milligrams in some cases.
Diseases like Sickle cell anemia, High Blood Pressure, Stroke, Chronic Heart Failure, Hypertrophic Cardiomyopathy, Pigmentary Retinopathy, and Multiple Myeloma are contraindicated with this medication. This is a major factor in deciding on the right dose for treatment. It is yet another aspect of treatment that patients who favor over the counter Sildenafil citrate need to be conversant with.
Some particular drugs should not be administered concomitantly with Sildenafil citrate. Only the lowest effective dose of the drug – 25 milligrams can be used in such cases. It is not out of place to administer this dose by cutting a stronger pill with the aid of a pill cutter or if you are considering an intermediate dose of 75 milligrams for instance. Remember to look up our TOP list of recommended pharmacies for the best place to get those.