Erectile Dysfunction drugs have come a long way. With the availability of so many oral therapies today, it is easy to forget that there was a time when the active pharmaceutical ingredients at the heart of these medications were administered via injection. The most popular of these ingredients today include Sildenafil (Viagra), Vardenafil (Levitra), and Tadalafil (Cialis).
These ingredients are still administered in the form of liquid injections but when they are administered via injection, it is to treat pulmonary arterial hypertension. The propensity to inhibit phosphodiesterase-5 is common to all three substances and it is a characteristic that is useful for treating both Erectile Dysfunction and PAH. Sildenafil and Vardenafil are structurally similar – making it a tricky task to decide on one over the other.
Sildenafil is produced and distributed by American multinational pharmaceutical corporation Pfizer under the following trade names: Viagra and Revatio. Vardenafil is produced and distributed by German pharmaceutical giant, Bayer, in conjunction with GlaxoSmithKline, and is marketed under the following trade names: Levitra, Staxyn, and Vivanza. The average prices of Brand Viagra and Levitra are $24.83 and $21 respectively.
Viagra and Levitra Side Effects
In addition to the aforementioned brand names, there are countless generic equivalents of these two medications. While brand name Sildenafil comes in twenty-five milligrams, fifty milligrams, and one hundred milligrams tablets, generic substitutes include intermediate doses of 75mg or extra doses of 200mg. Brand Levitra comes in 2.5mg, 5mg, 10mg, and 20mg tablets. Generic Levitra includes both intermediate and extra doses. Generic Viagra like Cenforce costs less than $1 on the average while generic Levitra like Filitra costs approximately $1 per pill.
The mechanism of action is similar in both drugs. Sildenafil and Vardenafil both inhibit the degradation of cyclic guanosine monophosphate in the corpus cavernosum by phosphodiesterase-5. This increases the presence of cGMP in the region and shortly thereafter, cGMP induces relaxation of smooth muscles in the region and dilation of penile blood vessels.
There are side effects associated with both Viagra and Levitra irrespective of brand name or dosage or formulation (film-coated tablets, orally disintegrating tablets, soft tablets, and others). The most commonly observed adverse reactions include Dyspepsia, Back Pain, Nasal Congestion, Headaches, and Flushing. These are mild compared to shortness of breath, Facial Edema, Priapism, Hypertension, Tachycardia, Insomnia, and Contact Dermatitis, to name a few of the more severe effects.
Temporary Color Blindness is one side effect that occurs occasionally with Sildenafil Citrate use but has not been associated with Vardenafil application. That and the slight difference between the half-lives of the two substances are the only notable differences between both medications. Vardenafil has a half-life of approximately four to five hours while Sildenafil has a half-life of approximately three to four hours.
Getting The Best Out of Sildenafil and How To Make Levitra More Effective
Both Sildenafil and Vardenafil should be ingested orally with an adequate amount of clean water. Sildenafil treatment is typically started with the fifty milligrams dosage strength. Subsequently, depending on observed tolerance and efficacy, the dosage is increased to one hundred milligrams. Orally disintegrating tablets and chewable tablets may increase the speed of absorption.
While extra doses of these medications increase the speed of absorption and efficacy, this increase comes with the danger of more and severe side effects. It would be wise to stick to the recommended dose to minimize side effects. It is, therefore, advisable to consult a professional medical practitioner for information regarding the danger of taking large doses of these substances as well as other necessary precautions.
A physician’s examination will focus on whether or not you are allergic to these APIs, if any of the medications you are currently taking contains nitrates, if you are currently taking medications made of nitric oxide donors, if you have a severe liver or heart condition, if you recently had a stroke or cardiac event, if you have hemophilia, and a few other areas. An online questionnaire on a vendor website may require some of this information.
It is best to take Sildenafil or Vardenafil at least thirty minutes before sexual activity. Alcohol, grapefruit juice, and food with a high percentage of fat should be minimized where possible – in fact, they are best avoided. These substances are detrimental to the effectiveness of these ED medications. Take one tablet of Brand or generic Levitra or Viagra once daily. Don’t take more than 20mg of the former or 100mg of the latter.
That is all you need to know about Sildenafil and Vardenafil therapies for Erectile Dysfunction. If you’re looking to shop on the Internet, you’re probably interested in generic Viagra or Levitra. As earlier alluded to, generic substitutes include intermediate doses of 75mg or extra doses of 200mg. Brand Levitra comes in 2.5mg, 5mg, 10mg, and 20mg tablets. Generic Levitra also includes both intermediate and extra doses.
Side effects have been observed in clinical trials for both of these medications. They are almost identical in this respect. Side effects include less severe effects like headaches, nasal congestion, stomach upset, facial flushing, hot flush, and severe side effects like Hypotension, Contact Dermatitis, Edema, Exfoliative Dermatitis, Tachycardia, Stevens-Johnson’s Syndrome, Insomnia, and Priapism.
In order to avoid the great majority of these side effects, it is best to see a qualified physician to better understand the risks associated with Erectile Dysfunction therapy in the form of these medications. If you decide to purchase your Erectile Dysfunction on the Internet, we recommend that you study our list of trustworthy online pharmacies and vendors before making a purchase decision.
Before shopping on the Internet, make sure that you are not currently on medications that contain nitrates or medication that is made of nitric oxide donors. Also make sure that you are not allergic to Sildenafil or Vardenafil, that you haven’t experienced a recent stroke or cardiac event, and that you don’t have hemophilia. Stick to the recommended dosage and do not use more than once a day. Remember to check our TOP list of recommended pharmacies for the best available prices.